WHAT ARE THE RISK FACTORS FOR ENDOMETRIAL CANCER (EC)?

It’s important to be aware of factors that may increase the risk of developing EC and talk to your doctor about any risk factors you may have.

SOME COMMON RISK FACTORS FOR ENDOMETRIAL CANCER INCLUDE:

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Personal History

  • Obesity

  • Age (risk increases with age)

  • High-fat diet

  • Lack of exercise 

  • History of testing positive for Lynch syndrome or another gene mutation linked to EC

  • Type-2 diabetes

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Reproductive History

  • Never having been pregnant

  • Polycystic ovarian syndrome (PCOS) (risk could be almost 3 times higher for people living with PCOS)

  • History of irregular periods 

  • Increased lifetime number of menstrual cycles

  • History of hormone therapy

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Family History

  • Family history of uterine cancer

  • Family history of colorectal cancer linked to Lynch syndrome

  • Family history of a relative testing positive for Lynch syndrome or another gene mutation linked to EC

FAMILY MEDICAL HISTORY MAY BE A RISK FACTOR

Family members discussing medical history on couch Family members discussing medical history on couch

A family history of certain conditions may increase your risk of endometrial cancer (EC). People in families with Lynch syndrome, also known as hereditary nonpolyposis colon cancer (HNPCC), have a higher risk of EC.

Other genetic risk factors include (but are not limited to) mutations in the PTEN gene. People with an inherited PTEN mutation may have a condition called Cowden syndrome.

Genetic counseling can give you information about how genetic conditions might affect you or your family, and genetic testing may help you to better understand if you might have an inherited risk for EC. You should consult with your doctor about whether to receive genetic counseling and testing.

HEALTH DISPARITIES AMONG COMMUNITIES OF COLOR

Three black women discussing endometrial cancer risk factors Three black women discussing endometrial cancer risk factors

Endometrial cancer (EC) may be more treatable when detected at an early stage. It’s especially important for Black women to recognize the symptoms, as only 53% of Black women with the condition receive an early-stage diagnosis.

Studies have found that there are a number of factors that contribute to increasing cases, deaths, and delayed diagnoses for Black women.

Among them are:

  • Socioeconomic status
  • Lack of access to care
  • Inequity in treatment
  • Biological factors
A survey of 15 Black women with EC showed that knowledge gaps around menopause and misinterpretation of bleeding symptoms may be associated with a delay in diagnosis. This delay may result in a later-stage diagnosis, when the cancer has spread. Endometrial cancer is easier to treat when found at an early stage, so it’s important to seek help and advocate for yourself.
It’s vital for all women
—especially Black women—
to speak to a doctor if you think you may have any of the risk factors or symptoms of EC.

The Black community is particularly vulnerable to EC since Black people with a uterus are more likely to be diagnosed with advanced-stage disease, have more aggressive tumor types, and face other healthcare disparities. In fact, Black women are twice as likely to die from EC compared to white women.

Black women are more often diagnosed with rare but aggressive forms of EC than white women, which is thought to contribute to an increased number of deaths. More aggressive tumor types accounted for 53% of deaths from EC among Black women, compared with 36% of deaths among white women.

HOW TO PUT YOUR HEALTH FIRST

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Learn about your family health history

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Know your body and document symptoms as they happen

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Visit your gynecologist regularly

After menopause, talk to your gynecologist about how often you should visit, and be sure to take any risk factors you may have into account when determining the frequency of visits.

If you are experiencing symptoms of endometrial cancer (EC), your doctor may use the following tests in order to understand the cause:

  • Pelvic examination
  • Ultrasound of the uterus
  • Biopsy of tissue from endometrium
  • Dilation and curettage with hysteroscopy

There are currently no routine screening tests for EC, so be sure to discuss any potential symptoms with your doctor right away. That way, they will be aware of any symptoms you may be having and can follow up appropriately.